Drug Delivery

COATSOME® ME-8181 (DOPE)

  • COATSOME® ME-8181 (DOPE)
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COATSOME ME-8181 (DOPE), or 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, is a ≥99% pure synthetic phospholipid. Featuring C18:1 fatty acids (18 carbon atoms, 1 double bond, oleic acid) at both the sn-1 and sn-2 positions, DOPE provides a small phosphoethanolamine headgroup, promoting membrane curvature and facilitating membrane fusion in lipid-based formulations.

DOPE is suitable for liposomal and lipid nanoparticle (LNP) formulations requiring high membrane flexibility, and supports the development of advanced drug delivery systems requiring enhanced membrane fusion or endosomal escape. Manufactured using highly purified fatty acids, ME-8181 offers consistent quality for pharmaceutical research and clinical applications.

DOPE is widely used as a helper phospholipid in lipid nanoparticle (LNP) and liposomal formulations to promote membrane fusion and support endosomal escape.

Acronym
DOPE
Alkyl Composition
R1COO= C18:1, R2COO= C18:1
Applications
LNP, Liposome and Lipid Complex
CAS Registry Number
4004-05-1
Chemical Name
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
MW
744
Package Size
1g, 10g
Product categories
Synthetic Phospholipids
Purity (%)
PE purity: 99% up
Package size
$330.00
$330.00
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