SUNBRIGHT® ME-3E050FH-MA

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SUNBRIGHT ME-3E050FH-MA is a pH-triggered releasable PEG derivative incorporating an acid-cleavable acetal linker, designed to release conjugated pharmaceutical substances under mildly acidic conditions (pH 4–6), such as in endosomes, lysosomes, or tumor tissues. It consists of a 5,000 Da PEG chain connected to an acid-cleavable linker that has a maleimide group as a functional group.

The acetal linker remains stable at physiological pH (7.4) while selectively cleaving under acidic environments to trigger drug release. The release rate can be fine-tuned by modifying the substituents on the benzene ring.

ME-3E050FH-MA offers excellent serum stability and storage stability, making it particularly suitable for targeted drug delivery systems requiring precise control of release timing in specific biological environments.

Applications Protein and Peptide Conjugate

Chemical Formula Maleimide-NHCO-CO₂CH₂-maleimide

Functional Groups Maleimide

MW 5,000

Package Size 100mg, 1g

PEG Type Releasable PEGs

Target Groups Thiol

Package Size

100mg amber glass bottle

1g amber glass bottle

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