SUNBRIGHT® BP2-400TS2

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SUNBRIGHT BP2-400TS2 is a degradable, 2-arm branched PEG derivative incorporating enzyme-cleavable peptide linkers within its structure. It consists of two 20 kDa PEG chains attached via enzyme-cleavable linkers to a core peptide structure, with an NHS carbonate group introduced near the branching point for efficient conjugation to amine-containing bioactive molecules.
The peptide linkers are designed to be stable in serum but selectively cleaved inside cells, such as within lysosomes, by enzymatic activity. This cleavage reduces the molecular weight of the PEG, facilitating enhanced clearance from the body compared to non-degradable PEGs. BP2-400TS2 maintains a comparable blood circulation profile to conventional non-degradable PEGs while facilitating faster clearance following intracellular degradation, contributing to improved pharmacokinetic behavior.
An important feature of degradable PEG is the ability to reduce the accumulation of high molecular weight PEGs in the body and to suppress cellular vacuolation, contributing to improved safety profiles in long term therapeutic use.
-NHCO-(CH2)5-O-CO2-NHS, Mw 40,000 (20,000x2)
Applications Protein and Peptide Conjugate
CAS Registry Number 2495047-56-6
Chemical Name 2-(1-oxo-6-succinimidyloxycarbonyloxyhexyl)amino-1,5-bis({3-[methylpoly(oxyethylene)-oxy]propylamino}glycyl-L-phenylalanyl)-1,5-dioxopentane
Functional Groups NHS carbonate
MW 40,000
Package Size 100mg, 1g
PEG Type Degradable PEGs
Target Groups Amine
Package Size
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