SUNBRIGHT® CS, GS, AS, PS, HS and TS Series (NHS active esters/Carbonate)

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We supply six types of monomethoxy-NHS activated ester/carbonate-PEGs that differ in terms of the NHS carboxylate attachment chemistry. The reactivity order of these linkers in aqueous solution from lowest to highest is HS<GS<TS<PS<CS<AS. After PEGylation, CS and GS types possessing ester groups are relatively susceptible to hydrolysis, whereas AS, PS, TS, and HS types are resistant to hydrolysis because of their different chemical structures. Therefore, our customers can select the appropriate type according to their goals among the six types available.

CS Type and AS Type PS Type and TS Type

Hydrolysis ratio of PEG-insulin (by using MeO-PEG-NHS type)

Hydrolysis ratio of PEG-insulin
Hydrolysis test was conducted in pH 8 buffer solution at 4°C. Leaving insulin was measured by HPLC/UV.
* HS type as well as AS type is stable (Hydrolysis test at 40°C).

Hydrolysis stability of activated ester and carbonate linker

Hydrolysis stability of activated ester and carbonate linker

Target groups: -NH2, -OH, -SH

Types

CS Type

Reactive group -CO-CH2CH2-COO-NHS
Target groups -NH2, -OH, -SH
CS Type structure

PS Type

Reactive group -CH2CH2-COO-NHS
Target groups -NH2, -OH, -SH
PS Type structure

GS Type

Reactive group -CO-CH2CH2CH2-COO-NHS
Target groups -NH2, -OH, -SH
GS Type structure

AS Type

Reactive group -CH2-COO-NHS
Target groups -NH2, -OH, -SH
AS Type structure

HS Type

Reactive group -CH2CH2CH2CH2CH2-COO-NHS
Target groups -NH2, -OH, -SH
HS Type structure

TS Type

Reactive group -COO-NHS
Target groups -NH2, -OH, -SH
TS Type structure