Drawing on our expertise in manufacturing both high-purity PEGs and lipids, NOF has been a global pioneer in the development of PEG diacylglycerols. Our products have been evaluated and adopted by companies worldwide.
High-Purity PEG Diacylglycerols — New
NOF supplies diacylglycerol-type PEG lipids with various PEG molecular weights and acyl chain lengths for LNP applications. We have now commercialized PEG lipids offering industry-leading purity.
By using highly purified raw materials, we produce high-quality PEG lipids with exceptional purity and extremely low impurity levels compared with PEG lipids available from other sources.
| Product name | Description | PEG MW | RCOO | |
|---|---|---|---|---|
| DMG-PEG2000 | SUNBRIGHT® GM-020EX | 1,2-Dimyristoyl-rac-glycero-3-methylpolyoxyethylene | 2,000 | C14:0 |
| DMG-PEG3400 | SUNBRIGHT® GM-034EX* | 1,2-Dimyristoyl-rac-glycero-3-methylpolyoxyethylene | 3,400 | C14:0 |
| DMG-PEG5000 | SUNBRIGHT® GM-050EX* | 1,2-Dimyristoyl-rac-glycero-3-methylpolyoxyethylene | 5,000 | C14:0 |
| DPG-PEG2000 | SUNBRIGHT® GP-020EX | 1,2-Dipalmitoyl-rac-glycero-3-methylpolyoxyethylene | 2,000 | C16:0 |
| DPG-PEG3400 | SUNBRIGHT® GP-034EX* | 1,2-Dipalmitoyl-rac-glycero-3-methylpolyoxyethylene | 3,400 | C16:0 |
| DPG-PEG5000 | SUNBRIGHT® GP-050EX* | 1,2-Dipalmitoyl-rac-glycero-3-methylpolyoxyethylene | 5,000 | C16:0 |
| DSG-PEG2000 | SUNBRIGHT® GS-020EX | 1,2-Distearoyl-rac-glycero-3-methylpolyoxyethylene | 2,000 | C18:0 |
| DSG-PEG3400 | SUNBRIGHT® GS-034EX* | 1,2-Distearoyl-rac-glycero-3-methylpolyoxyethylene | 3,400 | C18:0 |
| DSG-PEG5000 | SUNBRIGHT® GS-050EX* | 1,2-Distearoyl-rac-glycero-3-methylpolyoxyethylene | 5,000 | C18:0 |
| DOG-PEG2000 | SUNBRIGHT® GO-020EX* | 1,2-Dioleoyl-rac-glycero-3-methylpolyoxyethylene | 2,000 | C18:1 |
| DOG-PEG3400 | SUNBRIGHT® GO-034EX* | 1,2-Dioleoyl-rac-glycero-3-methylpolyoxyethylene | 3,400 | C18:1 |
| DOG-PEG5000 | SUNBRIGHT® GO-050EX* | 1,2-Dioleoyl-rac-glycero-3-methylpolyoxyethylene | 5,000 | C18:1 |
* Products marked with an asterisk (*) are made-to-order.
Activated PEG Diacylglycerols
NOF offers activated PEG diacylglycerols featuring a reactive group at the PEG terminal end. Conjugating a ligand to the PEG terminus can provide LNPs with active targeting capabilities.
| Product name | Description | -X | PEG MW | RCOO |
|---|---|---|---|---|
| SUNBRIGHT GS-020TS | 1,2-Distearoyl-rac-glycero-3-(succinimidyloxycarbonyl) polyoxyethylene | -COO-NHS | 2,000 | C18:0 |
| SUNBRIGHT GS-020MA | 1,2-Distearoyl-rac-glycero-3-(2′-maleimidoethyl) polyoxyethylene | -CH2CH2-Maleimide | 2,000 | C18:0 |