2-arm activated branched PEGs can introduce two PEG chains into pharmaceutical substances by a single linkage and improve the pharmacokinetic profile of the pharmaceutical substances efficiently *. 2-arm activated branched PEGs have already been used in some marketed PEGylated drugs.
- Yulia V. et al., Bioconjugate Chem., 23, 1452(2012).
GS2 Type (NHS-ester PEG)
TS Type (NHS-carbonate PEG)
NP Type (p-Nitrophenyl Carbonate PEG)
AL3 Type (Aldehyde PEG)
PA Type (Aminopropyl PEG)
Maleimide PEG
C2 Type
| Reactive group: | -(CH2)3-NHCO-(CH2)2-Maleimide |
C5 Type
| Reactive group: | -(CH2)3-NHCO-(CH2)5-Maleimide |
