SUNBRIGHT ME-3E050FH-MA is a pH-triggered releasable PEG derivative incorporating an acid-cleavable acetal linker, designed to release conjugated pharmaceutical substances under mildly acidic conditions (pH 4–6), such as in endosomes, lysosomes, or tumor tissues. It consists of a 5,000 Da PEG chain connected to an acid-cleavable linker that has a maleimide group as a functional group.
The acetal linker remains stable at physiological pH (7.4) while selectively cleaving under acidic environments to trigger drug release. The release rate can be fine-tuned by modifying the substituents on the benzene ring.
ME-3E050FH-MA offers excellent serum stability and storage stability, making it particularly suitable for targeted drug delivery systems requiring precise control of release timing in specific biological environments.
Maleimide
-NHCO-CO2CH2-maleimide, Mw 5,000
Package size: 100mg or 1g
*: make-to-order
