SUNBRIGHT GM-020 is a PEGylated lipid (commonly known as DMG-PEG2000) designed to enhance stability and efficiency of lipid nanoparticle (LNP) drug delivery systems. By incorporating polyethylene glycol (PEG) into the surface of LNPs, it improves the stability and circulation time of LNPs in the bloodstream, facilitating efficient delivery of encapsulated therapeutic agents such as mRNA, siRNA, and other nucleic acids.
Key Features:
- Enhanced Stability: The PEG moiety of GM-020 forms a hydrophilic layer around LNPs, reducing aggregation and increasing stability in biological environments.
- Prolonged Circulation: Extends the half-life of LNPs in the bloodstream, improving bioavailability of the encapsulated therapeutic agents and therapeutic outcomes.
- Efficient Delivery: Optimized for the encapsulation and transport of nucleic acids, GM-020 ensures effective delivery to target cells, enhancing therapeutic efficacy.
- Broad Applicability: Suitable for use in vaccines, gene therapies, and other nucleic acid-based therapeutics.
GM-020 is an essential component of LNPs to improve the delivery and performance of nucleic acid-based therapies, and is actually used in the COVID-19 mRNA vaccine.
Acronym: DMG-PEG 2,000
Chemical Name: 1,2-Dimyristoyl-rac-glycero-3-methylpolyoxyethylene
CAS#:
PEG chain Molecular weight: 2000
Alkyl composition: R1COO= C14:0, R2COO= C14:0
