SUNBRIGHT DSPE-050CN (DSPE-PEG5000) can be applied to lipid nanoparticle (LNP) and liposomal formulations to extend the half-life in the bloodstream. Coating of the surface of LNPs or liposomes with polyethylene glycol (PEG) suppresses drug clearance in vivo by the reticuloendothelial system, thereby prolonging the half-life of the drug.
Acronym: DSPE-PEG 5,000
Chemical Name: N-(Methylpolyoxyethylene oxycarbonyl)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, sodium salt
CAS#: 247925-28-6
PEG chain Molecular weight: 5000
Alkyl composition: R1COO= C18:0, R2COO= C18:0
