Browse by usage
Product line
Advanced search

PUREBRIGHT MA-P12-vc-pAB-NP*

For price request & purchasing:
4Non-Registered Users: Register HERE
4Registered Users: Request pricing thru " Product Inquiry " Tab below   å
" PRICE LINK "  will be sent by email * in office hours. 
Out-of-stock

PUREBRIGHT MA-P12-vc-pAB-NP is a cleavable pendant-type heterobifunctional monodisperse PEG linker designed for antibody-drug conjugates (ADCs), featuring two monodisperse PEG chains, two distinct functional groups a maleimide and a p-nitrophenyl carbonate—and a lysosomal enzyme-cleavable dipeptide unit combined with a self-immolative moiety, enabling controlled intracellular drug release under lysosomal conditions.

The pendant-like structure forms a hydrophilic domain that masks the hydrophobicity of payloads, enhancing aqueous solubility and improving pharmacokinetics. In vivo and in vitro studies demonstrated that ADCs prepared with MA-P12-vc-pAB-NP showed reduced aggregation, improved tolerability, extended circulation half-life, and enhanced anti-tumor efficacy compared to conventional non-PEGylated linkers.

MA-P12-vc-pAB-NP is particularly suited for the design of next-generation ADCs, where precise control over drug release, hydrophilicity, and linker architecture is critical for optimizing therapeutic performance.

Pendant EG12,

Maleimide-Val-Cit-pAB-p-NitroPhenyl Carbonate

Mw 2070.30

Package size: 100mg