SUNBRIGHT LP4-400AL2 is a degradable PEG derivative incorporating an enzyme-cleavable peptide linker within its structure. It consists of a linear 40 kDa PEG chain (20 kDa × 2) terminated with an aldehyde group, enabling selective conjugation to amine or aminooxy groups on bioactive molecules.
The peptide linker is designed to be stable in serum but selectively cleaved inside cells, such as within lysosomes, by enzymatic activity. This cleavage reduces the molecular weight of the PEG, facilitating enhanced clearance from the body compared to non-degradable PEGs. LP4-400AL2 maintains a comparable blood circulation profile to conventional non-degradable PEGs while facilitating faster clearance following intracellular degradation, contributing to improved pharmacokinetic behavior.
An important feature of degradable PEG is the ability to reduce the accumulation of high molecular weight PEGs in the body and to suppress cellular vacuolation, contributing to improved safety profiles in long term therapeutic use.
-NHCO-(CH2)3-CONH-(CH2)2-CHO
Mw 40,000 (20,000x2)
Package size: 100mg or 1g
