[Continued] 1-1. SS-cleavable and pH-responsive Lipid Like, Material (COATSOME® SS-Series)

 Degradation of COATSOME® SS-OP

 in vivo toxicity in comparison to a competitor lipid

 Feature

    • Encapsulation: siRNA, mRNA, pDNA
      • Efficient drug delivery into the cytoplasm of cells
      • Biodegradability and low toxicity
      • Controlled targeting of organs: liver, spleen, or lymph nodes
      • Long-term storage of lyophilized LNP at 25℃
      • Application to freeze-thaw LNP
      • Vaccine application (Humoral and Cellular immunity)

 Examples of application

With its high biocompatibility, COATSOME® SS Series enables the intracellular delivery of various compounds with high efficiency. COATSOME® SS Series particles can encapsulate pDNA, siRNA, mRNA and hydrophobic low molecular weight compounds, and has been proven in delivery targeting tumor, spleen, lymph node and brain.

In the following we will introduce data on hepatic siRNA delivery, hepatic mRNA delivery data and lymphatic mRNA delivery data for RNA vaccine application as examples.

 Formulations

Hepatic delivery of siRNA

 Distribution of [3H] labeled LNPSS-EC                       

 Hepatic delivery of mRNA

 Gene editing (CRISPR/Cas9)

 CTL activity

 Humoral immunity

 Therapeutic anti-tumor effect

 Low-inflammatory LNP-based mRNA vaccine New

 in vitro transfection of mRNA

 Splenic delivery formulation 

 Lyophilized LNP  

Freeze-thaw LNP New

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