6. Degradable PEGs
NOF has developed novel degradable PEGs that have enzyme cleavable peptide linkers.
Degradable PEGs have the same blood circulation time as non-degradable PEGs and are removed from the body faster than non-degradable PEGs because they are cleaved to lower molecular weight PEG in cells.
Degradable PEGs in cells were completely degraded by intracellular enzymes.
Additionally, degradable PEGs were stable in the serum as same as non-degradable PEGs.