{"product_id":"sunbright-me-050al","title":"SUNBRIGHT® ME-050AL","description":"\u003cp\u003eSUNBRIGHT® ME-050AL is a methoxy PEG aldehyde with a 5,000 Da PEG chain. The aldehyde group selectively reacts with amine or aminooxy groups on bioactive molecules. By leveraging the pKa difference between the ε-amine of lysines and the α-amine of the N-terminus, the aldehyde group can be used for selective PEGylation under slightly acidic conditions (pH 4.5–6). This approach minimizes off-target reactions at lysine side chains, allowing preferential conjugation at the protein’s N-terminus and resulting in more homogeneous PEG–protein conjugates. Moreover, the initial Schiff base (imine) formed upon reaction with amine groups can be stabilized via reductive amination to yield a stable secondary amine linkage. This N-terminal PEGylation strategy has been employed in the development of commercial therapeutics such as Neulasta® (pegfilgrastim) and its biosimilars, demonstrating its utility and commercial viability in the biopharmaceutical field.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethoxy-PEG-(CH\u003csub\u003e2\u003c\/sub\u003e)\u003csub\u003e2\u003c\/sub\u003e-CHO, Mw 5,000\u003c\/strong\u003e\u003cbr\u003eChemical Name: α-Methoxy-ω-(3-oxopropoxy), polyoxyethylene\u003cbr\u003eCAS#: 125061-88-3\u003c\/p\u003e","brand":"NOF AMERICA","offers":[{"title":"1g amber glass bottle","offer_id":42285289570388,"sku":"161G98160101KK1G","price":132.0,"currency_code":"USD","in_stock":true},{"title":"10g aluminum pouch","offer_id":42285289603156,"sku":null,"price":1190.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0643\/8292\/6932\/files\/ME-AL.jpg?v=1761752438","url":"https:\/\/nofamerica.com\/products\/sunbright-me-050al","provider":"NOF AMERICA CORPORATION","version":"1.0","type":"link"}