{"product_id":"sunbright-bp2-400ts2","title":"SUNBRIGHT® BP2-400TS2","description":"\u003cdiv style=\"text-align: left;\"\u003eSUNBRIGHT BP2-400TS2 is a degradable, 2-arm branched PEG derivative incorporating enzyme-cleavable peptide linkers within its structure. It consists of two 20 kDa PEG chains attached via enzyme-cleavable linkers to a core peptide structure, with an NHS carbonate group introduced near the branching point for efficient conjugation to amine-containing bioactive molecules.\u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003e \u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003eThe peptide linkers are designed to be stable in serum but selectively cleaved inside cells, such as within lysosomes, by enzymatic activity. This cleavage reduces the molecular weight of the PEG, facilitating enhanced clearance from the body compared to non-degradable PEGs. BP2-400TS2 maintains a comparable blood circulation profile to conventional non-degradable PEGs while facilitating faster clearance following intracellular degradation, contributing to improved pharmacokinetic behavior.\u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003e \u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003eAn important feature of degradable PEG is the ability to reduce the accumulation of high molecular weight PEGs in the body and to suppress cellular vacuolation, contributing to improved safety profiles in long term therapeutic use.\u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003e \u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003e\u003cstrong\u003e-NHCO-(CH\u003cspan style=\"font-size: 8pt;\"\u003e2\u003c\/span\u003e)\u003cspan style=\"font-size: 10.6667px;\"\u003e5\u003c\/span\u003e-O-CO\u003cspan style=\"font-size: 8pt;\"\u003e2\u003c\/span\u003e-NHS, Mw 40,000 (20,000x2)\u003c\/strong\u003e\u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003e\u003c\/div\u003e\u003cdiv style=\"text-align: left;\"\u003e\u003c\/div\u003e","brand":"NOF AMERICA","offers":[{"title":"100mg amber glass bottle","offer_id":42782124998740,"sku":"161G981SDC03GA100F","price":132.0,"currency_code":"USD","in_stock":false},{"title":"1g amber glass bottle","offer_id":42782125031508,"sku":"161G981SDC01KK1G","price":561.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0643\/8292\/6932\/files\/BP2-400TS2_88f0a8a3-90a1-4d4d-aa40-1180d6502a66.jpg?v=1765817326","url":"https:\/\/nofamerica.com\/products\/sunbright-bp2-400ts2","provider":"NOF AMERICA CORPORATION","version":"1.0","type":"link"}